Michael Caligiuri, M.D.
Associate Director for Clinical Research
The Ohio State University Comprehensive Cancer Center
The Ohio State University Medical Center
College of Medicine and Public Health

Along with other Ohio State researchers, Michael Caligiuri has conducted research which provides new evidence that inflammation may play an important role in the development of certain types of leukemia. "This is more evidence that inflammation can be a component of cancer. It also provides another reason why nonsteroidal anti-inflammatory drugs are now being tested as possible cancer preventives," he said. The findings, which were made using a new transgenic mouse, suggest that the inappropriate production of cytokines might be an initiating event in some leukemias, "which is not the way we usually think about leukemia," Caligiuri said. Chronic inflammation has in recent years emerged as an important player in the genesis of some cancers. For example, people with pancreatitis, an inflammation of the pancreas, have a higher incidence of pancreatic cancer. And people with Helicobacter pylori infection, which causes a chronic inflammation that leads to ulcers, have a high incidence of lymphoma and stomach cancer, Caligiuri said.

(excerpted from onCampus, Vol. 30, no.15)

 View an Ohio State Impact basketball halftime feature on Dr. Caligiuri
and cancer survivor, Carl Stewart (2:00)

 View rotating scoreboard spot highlighting
Dr. Caligiuri (:30)


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